Sildenafil is excreted as metabolites predominantly inside the feces (about 80% of administered oral dose) also to a lesser extent within the urine (all around 13% from the administered oral dose). If taken having a significant-Body fat food, absorption is lessened; the time taken to achieve the most plasma concentration raises by all over one hour, and the maximum focus alone is decreased by practically just one-3rd.[37] Route of administration
Sildenafil really should not be taken by people that take nitrates for example nitroglycerin (glycerin trinitrate), as this will end in a extreme and likely deadly fall in blood pressure level.[three]
In America, Pfizer received two patents for sildenafil: one particular for its indicator to treat cardiovascular disease (promoted as Revatio) and A further for its indication to deal with erectile dysfunction (promoted as Viagra). The compound is the same beneath both equally trade names.[75]
Get in touch with your health practitioner or look for unexpected emergency medical focus In the event your erection is painful or lasts more time than four hours. A chronic erection (priapism) can destruction the penis.
You can find yet another way to just take VIAGRA with you once you require it. VIAGRA Single Packs come in fifty mg and one hundred mg doses and also have the identical prescription coverage as VIAGRA pills you can get inside of a bottle.
The wellbeing info contained herein is furnished for educational needs only and isn't intended to swap discussions by using a healthcare supplier. All conclusions concerning client treatment has to be designed having a Health care service provider, contemplating the exceptional characteristics in the affected individual.
Sildenafil is in a category of remedies termed phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by expanding blood move into the penis all through sexual stimulation. This increased blood move could potentially cause an erection. Sildenafil treats PAH by enjoyable the blood vessels during the lungs to permit blood to move quickly.
Some sufferers expert a unexpected lack of some or all of their vision after they took sildenafil or other drugs which might be just like sildenafil. The eyesight decline was permanent in some cases. It isn't identified In case the eyesight reduction was a result of the medication.
g., angulation, cavernosal fibrosis, or Peyronie's disease); or diabetes. Also convey to your medical doctor for those who or any of the relatives have or have ever experienced a watch condition which include retinitis pigmentosa (an inherited eye situation that triggers lack of vision) or Should you have ever had unexpected severe vision decline, especially if you have been explained to that the vision decline was caused by a blockage of blood circulation into the nerves that assist you to see.
Sildenafil and/or N-desmethylsildenafil, its big Energetic metabolite, may be quantified in plasma, serum, or total blood to assess pharmacokinetic position in People receiving the drug therapeutically, to substantiate the prognosis in potential poisoning victims, or to aid inside the forensic investigation inside of a scenario of fatal overdose.[34] System of action
Sildenafil and various PDE5 inhibitors are utilised off-label to ease vasospasm and handle intense ischemia and ulcers in fingers and toes for individuals with secondary Raynaud's phenomenon;[nine][10] these medications have moderate efficacy for minimizing the frequency and period of vasospastic episodes.
Yet another manufacturer of sildenafil is Revatio, that is applied click here to treat pulmonary arterial hypertension and boost training capability in Gentlemen and girls.
In case you are using sildenafil to deal with erectile dysfunction, you should know that it does not remedy erectile dysfunction or improve sexual want. Sildenafil does not prevent pregnancy or the distribute of sexually transmitted health conditions which include human immunodeficiency virus (HIV).
Sildenafil has been studied for prime-altitude pulmonary edema but its use is at the moment not encouraged for that indicator.[11] Adverse effects